Jeremy Piven from Entourage and Mister Selfridge visits Dom on this episode to discuss Jeremy's recent entry into stand up comedy as well as his work on stage and television. This episode provides a glimpse into both of their backgrounds as actors and their transitions into stand up comedy.

Ruben Paul and his friend, Michael Bearden, guest on this episode to talk with Dom Irrera about Ruben's Haitian upbringing, the cultural benefits of performing internationally, and a Micheal Jackson painting that was a gift from Russell Peters.

Maz Jobrani visits the Laugh Factory and talks with Dom about his character on the sitcom "Superior Donuts" and generating comedy from politics and world affairs. 

Ismo visits the Laugh Factory a week after his appearance on Conan. Dom talks with Ismo about doing comedy in America, writing jokes in two languages, and marriage in the Finland.

Maronzio Vance and Dom are live on this episode full of talk about the beginning a career, sacrificing relationships for comedy, and the comedy business at large.

Jessimae Peluso guests on this episode to talk with Dom about tending to family health concerns, comedy on the road, and not taking life so seriously.

Eleanor Kerrigan catches up with Dom to talk about past career as a wrestler, her favorite family members, and starting her stand up career.

In this episode, Dom talks with guest Kate Quigley about comedy.

Caleb Synan takes a go as Dom Irrera's co-host on this month's show. 

Comedy writer Steve Skrovan guests recounting his TV writing career, stand-up comedy legends, and working with Ray Romano.