Dom talks to comedian, actor, and producer Shawn Wayans. They discuss growing up as a Wayans brother, rasing his own kids, late night talk shows, and his upcoming projects. 

Frazer Smith re-joins Dom's podcast and talks with Dom and Jamie Masada about the origins of the Laugh Factory. And as Jamie interrupts Frazer throughout the show, Dom becomes more upset. 

Dom talks with standup Donnell Rawlings, famous for playing Ahsy Larry on Chappelle's Show. They discuss The Chappelle show, race relations and Paula Deen.

Dom chats with comedian Greg Fitzsimmons. They discuss the trials of producing a podcast, his history in the Boston comedy scene, and Greg's habitual lateness.

Dom talks with Jeremy Hotz, who makes his second appearance on the show, to discuss the worst movies in the world, his birth in Africa and upbringing in Canada, and of course, standup comedy.

Comedian Jimmy Dore, of the hit radio show the Jimmy Dore Show, joins Dom to talk about medications, joke thieves, and his radio program. 

Dom talks with comedian and wood worker John DiResta about his time as a cop, his family life, and mobile porn.

Bil Dwyer joins Dom to talk about working about a random assortment of things, including props on stage, working on Battle Bots, twins, fights and the wisdom of Dom Irrera. 

Dom talks to legendary Latino comedian Paul Rodriguez on his early life in the military, doing standup from a young age, and knowing Rodney Dangerfield. 

Comedian/actor Owen Smith joins Dom to talk about commercial acting, playing basketball and the ups and downs of standup.